Response of human dental pulp to calcium hydroxide paste preceded by a corticosteroid/antibiotic dressing agent

The application of antiinflammatory agents on exposed pulp tissue in an attempt to prevent or minimize inflammatory reaction and to favor healing has been investigated for a long time. Corticosteroid can be used as a dressing agent for deep cavities and exposed pulp tissue in order to control the inflammatory pulp response and reduce postoperative pain. However, there is no consensus in the dental literature concerning the use of this medicament. Topic corticosteroid application for 5 min on the cavity floor did not significantly change intrapulpal pressure when compared to healthy teeth.

The therapeutic effect of a corticosteroid agent seems to depend upon its potency, concentration and ability to diffuse into connective tissue. Otosporin®, one of the commercial denominations of hydrocortisone /antibiotic association, presents high displacement capacity in dentin in comparison to other corticosteroid agents available to different therapies.