“The Morphogenesis, Pathogenesis, and Molecular Regulation of Human Tooth Development—A Histological Review” offers a rigorous and extensively illustrated synthesis of the biological events that shape tooth formation.
This review integrates classic histological concepts with modern molecular discoveries, highlighting the orchestrated signaling pathways, epithelial–mesenchymal interactions, and genetic determinants that guide each developmental stage.
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The article also examines how disruptions in these tightly regulated processes may lead to congenital dental anomalies, shedding light on the pathogenesis of conditions such as tooth agenesis, supernumerary teeth, and structural defects of enamel and dentin.
By bridging foundational embryology with emerging molecular evidence, this review provides clinicians, researchers, and students with a clear roadmap of the mechanisms that define normal and abnormal odontogenesis.
