PDF: Yeasts from the oral cavity of children with AIDS: exoenzyme production and antifungal resistance

The infection caused by HIV in children leads to deep immunosuppression, has a shorter incubation period than in adults, and produces various manifestations that include oral symptoms. 

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These occur earlier in children and facilitate the development of opportunistic infections like fungal infections. The disease progression is faster and more severe in children, as they possess an immature immune system and are still undergoing development. 

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The early diagnosis of lesions and their complications is an important component in the treatment of children, particularly considering that candidiasis is one of the first signs of viral disease progression. Pseudomembranous candidiasis has a close correlation with the immune status of the patient, especially in symptomatic children, in whom reduced CD4+ leukocyte counts lead to an increase in the frequency and severity of AIDS-associated manifestations.

Among the first reports concerning AIDS are cases of children exhibiting early and unexplained immunodeficiencies associated with opportunistic infections, favored by intrauterine or post-birth transmission. Oral candidiasis and parotid enlargement are considered to be important signs of disease progression, guiding decisions during the treatment of children with AIDS.

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