PDF: Oral and Maxillofacial Manifestations of Systemic Diseases: What Every Clinician Should Recognize



The oral and maxillofacial region often serves as a mirror of systemic health, providing early and sometimes critical clues to underlying medical conditions.

The article Oral and Maxillo-Facial Manifestations of Systemic Diseases: An Overview, published in MDPI, offers a comprehensive synthesis of how systemic diseases can present with signs and symptoms in the oral cavity, jaws, and facial structures.


This overview highlights the diagnostic value of oral manifestations associated with metabolic disorders, autoimmune diseases, hematologic conditions, infectious diseases, and systemic malignancies.

By correlating clinical findings in the oral and maxillofacial area with broader systemic pathologies, the authors emphasize the crucial role of dentists, oral medicine specialists, and physicians in early detection, interdisciplinary collaboration, and timely referral.


Understanding these manifestations is essential not only for accurate diagnosis, but also for improving patient outcomes, as oral signs may precede systemic symptoms or signal disease progression.

This article reinforces the importance of viewing oral health as an integral component of overall health, particularly in complex or multisystemic conditions.

👉 For an in-depth analysis, detailed clinical correlations, and illustrative examples, we invite you to read the full article available in PDF format, accessible through the official publication platform.

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