PDF: Pioneering Endodontic Regeneration: Stem Cell Strategies & Tissue Engineering in Modern Dentistry



Endodontic regenerative therapy represents a transformative frontier in dental medicine, shifting the paradigm from conventional root canal treatments toward biologically driven restoration of pulp and periapical tissues.

Traditional endodontic procedures focus on eradicating infection and filling the root canal system, often at the expense of the tooth’s intrinsic biological functions.


In contrast, regenerative approaches explored in this comprehensive review harness advances in stem cell biology, biomaterials, and tissue engineering to restore the natural architecture and functionality of dental pulp and surrounding bone structures.


By integrating vital pulp therapy, cell-based and cell-free regenerative strategies, and cutting-edge engineering solutions, this article offers a current, in-depth overview of how regenerative endodontics aims to preserve vitality, promote structural regeneration, and improve long-term clinical outcomes in cases of pulpitis, necrosis, and apical periodontitis.

👉 Read the full open-access PDF of the article “Endodontic Regeneration Therapy: Current Strategies and Tissue Engineering Solutions to explore detailed mechanisms, clinical strategies, and future directions in regenerative endodontics.

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