PDF: Low-level Laser Therapy for Oral Mucositis during Radiotherapy: Clinical Evidence from a Double-blind Trial (2022)



Oral mucositis (OM) remains one of the most painful and disabling side effects of radiotherapy in patients with head and neck cancer, often exacerbated when combined with chemotherapy.

This inflammatory condition of the oral mucosa can significantly impair a patient's quality of life by limiting food intake, increasing the risk of systemic infections, and even interrupting cancer treatment schedules.


In the randomized double-blind clinical trial titled “Low-level Laser Therapy in the Management of Oral Mucositis Induced by Radiotherapy”, researchers evaluated the therapeutic efficacy of low-level laser therapy (LLLT) as a non-pharmacological intervention to reduce the severity of OM.

The study results showed that patients who received LLLT—especially those treated with a combination of red and infrared laser—demonstrated a statistically significant reduction in the severity of mucositis (p = 0.012), although pain levels did not differ significantly compared to the control group (p = 0.49).


These findings underscore the potential of LLLT as a safe, non-invasive, and clinically effective adjunct in the management of radiation-induced OM

Its application could enhance patient comfort and treatment continuity in oncology-focused dental care.

👉 We invite dental professionals around the world to explore the Full article in PDF and gain deeper insights into the methodology, results, and practical implications of this important clinical study.


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