To manage this discomfort, non-steroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed or self-administered due to their well-established analgesic and anti-inflammatory properties.
However, beyond pain control, NSAIDs may exert biological effects that influence the cellular and molecular mechanisms responsible for orthodontic tooth movement.
Orthodontic tooth movement is a complex process driven by inflammation-mediated bone remodeling, where prostaglandins play a key regulatory role.
Since NSAIDs act primarily by inhibiting cyclooxygenase (COX) enzymes and reducing prostaglandin synthesis, concerns have emerged regarding their potential to slow tooth movement, alter treatment efficiency, or impact overall orthodontic outcomes.
These effects may vary depending on the type of NSAID, dosage, duration of use, and selectivity for COX-1 or COX-2 pathways.
► DENTAL BOOK: Orthodontics - Diagnosis and Management of Malocclusion and Dentofacial Deformities - Om Prakash Kharbanda
This comprehensive review critically examines the current scientific evidence on the effects of NSAIDs used for orthodontic pain management on tooth movement.
By analyzing findings from in vitro studies, animal models, and clinical trials, the article provides valuable insights into which analgesic strategies may be safer for orthodontic patients, helping clinicians balance effective pain relief with optimal biomechanical response.
👉 To explore the complete analysis, methodology, and clinical recommendations, we invite you to read the full article available in PDF format.
