PDF: Evaluation of an oral preventive protocol in children with acute lymphoblastic leukemia


This study was designed to assess the effectiveness of a preventive oral protocol in children receiving antineoplastic treatment for acute lymphoblastic leukemia (ALL) before initiating a larger intervention study.



During a seven month period, fourteen children from two to ten years old with a diagnosis of ALL were evaluated.

Patients with ALL who received a 0.12% chlorhexidine mouth rinse (seven children) were compared to a control group of patients who were not given the same preventive treatment (seven children) as to the occurrence of oral mucosal complications. 


Children in both groups received daily oral hygiene care, and were examined daily by the pediatric dentistry team until discharge.

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