The recently published systematic review by Gazzani et al. (2025) titled “The Role of the Interproximal Enamel Reduction in Orthodontics: A Systematic Review” synthesizes the existing literature up to March 2025, evaluating clinical indications, procedural techniques and biological consequences associated with IPR.
Analyzing 420 initially identified publications — of which only 23 met the rigorous inclusion criteria — the authors report that in all reviewed studies, IPR demonstrated effectiveness as a non-extraction space-gaining method without evidence of detrimental outcomes such as enamel demineralization, surface irregularities, increased caries incidence, or periodontal compromise.
Notably, the review highlights that oscillating mechanical techniques achieve superior results compared to manual methods: delivering more predictable enamel reduction, greater efficiency, and better preservation of enamel integrity.
Nonetheless, the authors emphasize that the overall quality of the evidence remains low, underlining the pressing need for more randomized controlled trials, longer follow-up periods, and standardized protocols to establish robust clinical recommendations.
In light of the increasing demand for non-extraction orthodontic approaches and the pivotal role of IPR in contemporary treatment planning, this review represents a significant update: consolidating current evidence, clarifying benefits and potential biological risks, and illuminating critical gaps in knowledge.
For orthodontists, dental researchers and educators, the findings provide a useful, consolidated reference to support evidence-based decisions and guide future research.
👉 We invite you to read the full systematic review — available as open-access PDF — to delve deeper into the methodology, detailed findings, discussion, and clinical implications.
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