This systematic review titled 'Effectiveness and Clinical Indications of 2 × 4 Fixed Orthodontic Therapy in Regard to Mixed Dentition: A Systematic Review' addresses a key question in early interceptive orthodontics: how effective is the 2 × 4 fixed appliance in children during the mixed-dentition stage, and under which clinical circumstances is it most appropriately applied?
The authors conducted a rigorous literature search (PubMed, Web of Science, Scopus; May 2000–May 2025) and applied the PRISMA guidelines to evaluate human in-vivo studies, cohorts, and randomized controlled trials.
Their findings provide a comprehensive synthesis of 25 years of evidence, underscoring that the 2 × 4 appliance demonstrates strong effectiveness as an interceptive therapy—particularly for anterior malocclusion management in the mixed-dentition phase.
The review further discusses biomechanics, patient-management issues, clinical protocols, and highlights gaps in long-term data and diagnostic precision.
For dental practitioners, orthodontists and educators alike, the article offers valuable insights on how and when to employ the 2 × 4 fixed appliance to optimize outcomes, reduce the need for more complex treatments later on, and guide decision-making in early orthodontic care.
👉 We invite you to access and Download the full article in PDF format from the publisher’s site to explore the detailed methodology, study characteristics, risk-of-bias assessment, tables, figures, and clinical implications.
