A filling-free future? Science is getting closer.
Among the emerging non-invasive dental technologies gaining real clinical traction, P11-4 peptide, the basis of the product Curodont Repair, stands out as a game-changer in biomimetic remineralisation.
What is P11-4?
P11-4 is a synthetic self-assembling peptide designed to mimic the natural scaffolding process of enamel formation.
When applied to early enamel caries, it penetrates the porous lesion and forms a 3D nanomatrix that guides crystal growth of hydroxyapatite from available calcium and phosphate ions.
This process restores mineral content deep within the lesion, beyond the capabilities of conventional fluoride treatments.
How does Curodont Repair work?
1. The P11-4 gel is applied to a non-cavitated carious lesion (ICDAS 1 or 2)
2. The peptide infiltrates the enamel porosity
3. It self-assembles into a nanofiber matrix inside the lesion
4. The matrix attracts calcium and phosphate ions, promoting guided tissue remineralisation
Clinical benefits of Curodont Repair
✔️ Non-invasive, no anesthesia or drilling
✔️ Ideal for children and anxious patients
✔️ Supports deep, guided enamel regeneration
✔️ Can halt or reverse initial caries lesions
✔️ Easy to apply in clinics and outreach settings
► GUIDANCE: Prevention and Management of Dental Caries in Children - Third Edition (2025)
Indications
✔ Early-stage enamel caries (ICDAS 1 & 2)
✔ Post-orthodontic white spot lesions
✔ Preventive treatment in high-risk patients
✔ A proactive alternative to “watch and wait” approaches
Real-world adoption
Curodont Repair is approved for clinical use in Europe and is expanding globally.
It is especially valued in minimally invasive and pediatric dentistry, and is part of the movement toward biologically driven caries management.
📚 Recommended reference
- Scientific Reports volume 15, Article number: 11512 (2025). Evaluation of the efficacy of P11-4 and CCP-ACPF in the prevention and treatment of white spot lesions: a multi-technique approach
