Microorganisms and their by-products play a critical role in pulp and periradicular pathosis. Therefore, one of the main purposes of root canal treatment is disinfection of the entire system of the canal.
This aim may be obtained using mechanical preparation, chemical irrigation, and temporary medication of the canal.
For this purpose, various irrigation solutions have been advocated. Common root canal irrigants, such as sodium hypochlorite, chlorhexidine, and a mixture of tetracycline, acid, and detergent have been extensively reviewed.
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The aim of this review was to address the less common newer root canal irrigation solutions, such as citric acid, maleic acid, electrochemically activated water, green tea, ozonated water, and SmearClear.
The important role of microorganisms in the pathogenesis of pulpoperiapical lesions has been proved.
Decrease in amount of microorganisms inside the infected canal needs usage of the various instrumentation techniques, irrigation solutions, and intracanal temporary medicaments.
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Mechanical preparation of the canal alone cannot induce a bacteria-free canal, especially in cases with complexanatomy.
On the contrary, ex vivo and clinical documents have indicated that mechanical preparation of the canal leaves large portions of the canal walls undebrided and complete removal of the bacteria by this mechanical procedure alone is unlikely to be seen.